Dan (Robin Williams) and Charlie (John Travolta) have been the best of friends for most of their lives. Seeing each other through childhood and adolescence, they went on to develop an incredibly successful business together, as adults. Charlie stood by, as a friend, while Dan’s marriage fell apart and he tried to pick up the pieces of his life—just as Dan stood by non-judgmentally as Charlie lived the life of a playboy with expensive tastes and many women. Just after Dan’s divorce, Charlie even went as far as to take Dan to Miami, in an attempt to party the sadness out of him and convert Dan to his own careless and free way of living.
Instead, after a tattoo venture gone wrong, Dan met Vicki (Kelly Preston). Believing what they shared was love at first sight, he and Vicki were wed in a quickie chapel, only for Charlie to convince Dan to annul the marriage almost as quickly as it began, and walk away from Vicki forever.
Seven years later, and on the eve of an enormous opportunity for their company, Dan’s second ex-wife Vicki drops in to pay him a visit. Over those past years, Dan has battled himself over whether or not Vicki had actually been the love of his life. Her asking to meet with him, out of the blue, leads him to believe that she feels the same way. The very last thing Dan expects to hear is that he is the father of her 7 year old Twins Zach and Emily.
What follows seems to be one calamity after another, taking each of these men on a journey to becoming much better versions of themselves…